Antibody Identity card
CD274 mouse specific (Programmed death ligand 1, PDL-1) Protein
Protein information
Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function.
Protein link information
Validation / characterisation
- Working
- No conclusive
- Not working
- Not tested
- CLONE NAME
- APPLICATIONS