EuroMAbNet: European Monoclonal Antibodies Network

mAbs Against HUMAN Protein

CD45RA

CONTACT INFORMATION:	University of Oxford marketed by Ximbio.com
TYPE:	mouse anti human
CLONE NAME:	4KB5
PROTEIN:	Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45RA)
PROTEIN WEB:	https://www.omim.org/entry/151460
ANTIGEN USED:	B cell lymphoma
FUSION PARTNER:	P3/NS1/1-Ag4.1
ISOTYPE:	IgG1 kappa
SPECIES REACTIVITY:	Human
PREPARATION AND STORAGE:	Aliquot and store at 4C. Do not freeze
COMMERCIALIZED BY:	Ximbio.com
APP RECOMMENDED:	FACS IHC IP WB

DESCRIPTION

PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45RA is an isoform of the PTPRC (CD45) protein which is selectively expressed on B cells.

REFERENCES

Pulford KAF et al. 1987. In: McMichael A, et al (eds) Leucocyte Typing III. Oxford University Press, Oxford, New York and Tokyo, p 828

Blood. 2005 Apr 15;105(8):3295-302. Epub 2004 Dec 30.
A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma.
Li FJ1, Tsuyama N, Ishikawa H, Obata M, Abroun S, Liu S, Otsuyama K, Zheng X, Ma Z, Maki Y, Kawano MM.
PMID: 15626731
https://www.ncbi.nlm.nih.gov/pubmed/15626731

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