mAbs Against HUMAN Protein
CD45RB
| STATUS: | |
|---|---|
| CONTACT INFORMATION: | University of Oxford marketed by Ximbio.com |
| TYPE: | mouse anti human |
| CLONE NAME: | PD7/26 |
| PROTEIN: | Protein tyrosine phosphatase |
| PROTEIN WEB: | https://www.omim.org/entry/151460 |
| ANTIGEN USED: | Human PBL maintained in T-cell growth factor |
| FUSION PARTNER: | P3/NS1/1-Ag4.1 |
| ISOTYPE: | IgG1 |
| SPECIES REACTIVITY: | Human |
| PREPARATION AND STORAGE: | Aliquot and store at 4C. Do not freeze |
| COMMERCIALIZED BY: | Ximbio.com |
| APP RECOMMENDED: | FACS IHC IF WB |
Description
PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45RB is an isoform of the PTPRC (CD45) protein which is expressed on peripheral B cells, T cytotoxic cells and CD4+ T cells. It has a role in cell signalling regulation through the activation of the Src family of tyrosine kinases. PD7/26 is widely used, in conjunction the CD45 antibody 2B11, to detect white cell-derived tumours in paraffin sections.
Publication describing antibody characterization/validation
N Engl J Med. 1983 Nov 24;309(21):1275-81.
Diagnosis of human lymphoma with monoclonal antileukocyte antibodies.
Warnke RA, Gatter KC, Falini B, Hildreth P, Woolston RE, Pulford K, Cordell JL, Cohen B, De Wolf-Peeters C, Mason DY.
PMID: 6355845
https://www.ncbi.nlm.nih.gov/pubmed/6355845