EuroMAbNet: European Monoclonal Antibodies Network

mAbs Against HUMAN Protein

CD79a

CONTACT INFORMATION:	University of Oxford marketed by Ximbio.com
TYPE:	mouse anti human
CLONE NAME:	JCB117
PROTEIN:	CD79a
PROTEIN WEB:	https://www.omim.org/entry/112205
ANTIGEN USED:	Synthetic peptide of 14 amino acids representing residues 202-216 of the human mb-1 cDNA sequence
FUSION PARTNER:	P3/NS1/1-Ag4.1
ISOTYPE:	IgG1
SPECIES REACTIVITY:	Human
PREPARATION AND STORAGE:	Aliquot and store at 4C. Do not freeze
COMMERCIALIZED BY:	Ximbio.com
APP RECOMMENDED:	IHC WB

DESCRIPTION

The B-cell Antigen receptor constitutes a disulphide linked heterodimer, consisting of CD79a (mb1) and CD79b / B29 polypeptides which are non-covalently associated with membrane bound immunoglobulins on B-cells. CD79a first appears at pre B-cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in B-cell lymphomas, in B-cell lines, the majority of acute leukemias of precursor B-cell type and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). The induction of tyrosine kinase activity after antigen binding leads to phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signalling. CD79a is widely used as an adjunct to CD20 as a biomarker for normal and neoplastic B-cells in tissues sections.

PUBLICATION DESCRIBING ANTIBODY CHARACTERIZATION/VALIDATION

Blood. 1995 Aug 15;86(4):1453-9.
CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples.
Mason DY1, Cordell JL, Brown MH, Borst J, Jones M, Pulford K, Jaffe E, Ralfkiaer E, Dallenbach F, Stein H, et al.
PMID: 7632952
https://www.ncbi.nlm.nih.gov/pubmed/7632952

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