EuroMAbNet: European Monoclonal Antibodies Network

TOX (Thymocyte Selection Associated High Mobility Group Box) Protein

Protein information

Thymocyte selection-associated high-mobility group box (TOX) is a member of a small subfamily of proteins (TOX2, TOX3 and TOX4) that share almost identical High Mobility Group (HMG)-box sequences and are highly conserved between mice and humans. HMG proteins contain DNA-binding domains that allow them to produce specific changes in target DNA structure and modulate the formation of multi-protein complexes. TOX plays a key role in T cell development in the thymus during positive selection. A study in Tox-deficient mice also revealed a requirement for Tox in CD4 T cell and NK cell lineage development, including NKT cells, FoxP3+ T regulatory T cells, and lymphoid tissue-inducer cells.

Protein link information

Validation / characterisation

• Working
• No conclusive
• Not working
• Not tested

• CLONE NAME
• APPLICATIONS

Applications legend

• WB: Western blotting
• ICC: Immunocytochemistry
• IHC-P: Immunohistochemistry - Paraffin
• IF-F: Immunoflourescence - Frozen
• IF-P: Immunoflourescence - Paraffin
• FLOW: Flow cytometry
• IHC-P Species: Immunohistochemistry - Paraffin Species