mAbs Against HUMAN Protein
CD2
| STATUS: | |
|---|---|
| CONTACT INFORMATION: | University of Oxford marketed by Ximbio.com |
| TYPE: | mouse anti human |
| CLONE NAME: | X53 (X/3) |
| PROTEIN: | CD2 |
| PROTEIN WEB: | https://www.omim.org/entry/186990 |
| ANTIGEN USED: | T cell lymphoma cells |
| FUSION PARTNER: | P3/NS1/1-Ag4.1 |
| ISOTYPE: | IgG1 kappa |
| SPECIES REACTIVITY: | Human |
| PREPARATION AND STORAGE: | Aliquot and store at 4C. Do not freeze |
| COMMERCIALIZED BY: | Ximbio.com |
| APP RECOMMENDED: | FACS IHC |
Description
T-cell surface antigen CD2 is an antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3/ CD58) and CD48/BCM1 to mediate adhesion between T cells and other cell types. Intracellularly, it interacts with lck. CD2 can be used for monitoring T-cell number in periperal blood, and identification of lymphomas and leukaemias of T-cell origin.
References
CD guide for CD2 (1989) Leukocyte Typing IV, Oxford University Press, Oxford, New York and Tokyo; p1074-1075
Pawelec G et al. 1989. Stimulatory capacity of Workship T-cell antibodies on T-lymphocyte clones. Leukocyte Typing IV, Oxford Univeristy Press, Oxford, New York and Tokyo; p310-311.2.