mAbs Against HUMAN Protein
CD21L
| STATUS: | |
|---|---|
| CONTACT INFORMATION: | University of Oxford marketed by Ximbio.com |
| TYPE: | mouse anti human |
| CLONE NAME: | R4/23 |
| PROTEIN: | Complement component (3d/Epstein Barr virus) receptor 2; long form (CR2, CD21L) |
| PROTEIN WEB: | https://www.omim.org/entry/120650 |
| ANTIGEN USED: | Cell lysate from a chronic lymphocytic leukemia patient. |
| FUSION PARTNER: | P3/NS1/1-Ag4.1 |
| ISOTYPE: | IgM |
| SPECIES REACTIVITY: | Human |
| PREPARATION AND STORAGE: | Aliquot and store at 4C. Do not freeze |
| COMMERCIALIZED BY: | Ximbio.com |
| APP RECOMMENDED: | IHC WB |
Description
CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the “Long” isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21). R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues.
Publication describing antibody characterization/validation
J Clin Pathol. 1983 Feb;36(2):167-75.
Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.
Naiem M, Gerdes J, Abdulaziz Z, Stein H, Mason DY.
PMID: 6338047
https://www.ncbi.nlm.nih.gov/pubmed/6338047