mAbs Against HUMAN Protein
|CONTACT INFORMATION:||University of Oxford marketed by Ximbio.com|
|TYPE:||mouse anti human|
|PROTEIN:||Complement component (3d/Epstein Barr virus) receptor 2; long form (CR2, CD21L)|
|ANTIGEN USED:||Cell lysate from a chronic lymphocytic leukemia patient.|
|PREPARATION AND STORAGE:||Aliquot and store at 4C. Do not freeze|
|APP RECOMMENDED:||IHC WB|
CR2 is expressed strongly on mature B cells, follicular dentritic cells and weakly on immature thymocytes and T lymphocytes. CR2 functions as a receptor for C3d, C3dg and iC3b Complement components and for EBV and for IFN alpha. Follicular dendritic cells (contained in B cell follicles) selectively express the “Long” isoform of CR2 (CD21L) that contains an additional exon (10a) compared to CR2 (CD21). R4/23 recognises the long form of CR2 and can be used to identify dendritic reticulum cells (or their remnants) in lymphoid tissues.
PUBLICATION DESCRIBING ANTIBODY CHARACTERIZATION/VALIDATION
J Clin Pathol. 1983 Feb;36(2):167-75.
Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue.
Naiem M, Gerdes J, Abdulaziz Z, Stein H, Mason DY.