mAbs Against HUMAN Protein
CD68
| STATUS: | |
|---|---|
| CONTACT INFORMATION: | University of Oxford marketed by Ximbio.com |
| TYPE: | mouse anti human |
| CLONE NAME: | Y1/82A |
| PROTEIN: | CD68 |
| PROTEIN WEB: | https://www.omim.org/entry/153634 |
| ANTIGEN USED: | Lysosomal contents of lung macrophages |
| FUSION PARTNER: | P3/NS1/1-Ag4.1 |
| ISOTYPE: | IgG2a |
| SPECIES REACTIVITY: | Human |
| PREPARATION AND STORAGE: | Aliquot and store at 4C. Do not freeze |
| COMMERCIALIZED BY: | Ximbio.com |
| APP RECOMMENDED: | FACS IHC IF WB |
Description
CD68 is a 110 kD glycoprotein, also known as macrosialin, belonging to the sialomucin family. It is closely related to the family of acidic, highly glycosylated lysosomal-associated membrane proteins (LAMPs). CD68 is predominately expressed in cytoplasmic granules of monocytes/macrophages, dendritic cells, and granulocytes. It is one of the useful myeloid cell markers. Further studies have shown that CD68 is also expressed by a subset of hematopoietic progenitors, γ/δ T cells, NK cells, LAK cells, subset of B cells, fibroblasts, and endothelial cells. The biological function of CD68 is still unknown.
References
Br J Haematol. 1989 Sep;73(1):6-11.
A human macrophage-associated antigen (CD68) detected by six different monoclonal antibodies.
Micklem K1, Rigney E, Cordell J, Simmons D, Stross P, Turley H, Seed B, Mason D.
PMID: 2803980
https://www.ncbi.nlm.nih.gov/pubmed/2803980