mAbs Against HUMAN Protein
|CONTACT INFORMATION:||University of Oxford marketed by Ximbio.com|
|TYPE:||mouse anti human|
|PROTEIN:||Sialic acid binding Ig-like lectin 2 (SIGLEC2, CD22, BL-CAM)|
|ANTIGEN USED:||B cell lymphoma cells|
|PREPARATION AND STORAGE:||Aliquot and store at 4C. Do not freeze|
SIGLEC-2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC-2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC-2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC-2 is strongly expressed in hairy cell leukaemias.
PUBLICATION DESCRIBING ANTIBODY CHARACTERIZATION/VALIDATION
Blood. 1987 Mar;69(3):836-40.
Value of monoclonal anti-CD22 (p135) antibodies for the detection of normal and neoplastic B lymphoid cells.
Mason DY, Stein H, Gerdes J, Pulford KA, Ralfkiaer E, Falini B, Erber WN, Micklem K, Gatter KC.