mAbs Against HUMAN Protein
SIGLEC2
| STATUS: | |
|---|---|
| CONTACT INFORMATION: | University of Oxford marketed by Ximbio.com |
| TYPE: | mouse anti human |
| CLONE NAME: | 4KB128 |
| PROTEIN: | Sialic acid binding Ig-like lectin 2 (SIGLEC2, CD22, BL-CAM) |
| PROTEIN WEB: | https://www.omim.org/entry/107266 |
| ANTIGEN USED: | B cell lymphoma cells |
| FUSION PARTNER: | P3/NS1/1-Ag4.1 |
| ISOTYPE: | IgG1 kappa |
| SPECIES REACTIVITY: | Human |
| PREPARATION AND STORAGE: | Aliquot and store at 4C. Do not freeze |
| COMMERCIALIZED BY: | Ximbio.com |
| APP RECOMMENDED: | FACS |
Description
SIGLEC-2 is first expressed in the cytomplasm of pre- and pro- B cells. SIGLEC-2 is broadly expressed in normal and neoplastic B cells and absent from other leucocytes and tissues. SIGLEC-2 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation. SIGLEC-2 is strongly expressed in hairy cell leukaemias.
Publication describing antibody characterization/validation
Blood. 1987 Mar;69(3):836-40.
Value of monoclonal anti-CD22 (p135) antibodies for the detection of normal and neoplastic B lymphoid cells.
Mason DY, Stein H, Gerdes J, Pulford KA, Ralfkiaer E, Falini B, Erber WN, Micklem K, Gatter KC.
PMID: 3101766
https://www.ncbi.nlm.nih.gov/pubmed/3101766