mAbs Against HUMAN Protein
TAL1
| STATUS: | |
|---|---|
| CONTACT INFORMATION: | University of Oxford marketed by Ximbio.com |
| TYPE: | mouse anti human |
| CLONE NAME: | BTL73 |
| PROTEIN: | T-cell acute lymphocytic leukemia 1 |
| PROTEIN WEB: | https://www.omim.org/entry/187040 |
| ANTIGEN USED: | TAL-1 recombinant protein |
| FUSION PARTNER: | P3/NS1/1-Ag4.1 |
| ISOTYPE: | IgG1 |
| SPECIES REACTIVITY: | Human |
| PREPARATION AND STORAGE: | Aliquot and store at 4C. Do not freeze |
| COMMERCIALIZED BY: | Ximbio.com |
| APP RECOMMENDED: | ChIP ELISA IHC WB |
Description
T-cell acute lymphocytic leukemia protein 1 (TAL1) is a basic helix-loop-helix transcription factor implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation, including a positive regulation of erythroid differentiation. Diseases associated with TAL1 include leukemia, acute lymphoblastic and precursor t-cell acute lymphoblastic leukemia. A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL).
Publication describing antibody characterization/validation
Blood. 1995 Feb 1;85(3):675-84.
Expression of TAL-1 proteins in human tissues.
Pulford K1, Lecointe N, Leroy-Viard K, Jones M, Mathieu-Mahul D, Mason DY.
PMID: 7833471
https://www.ncbi.nlm.nih.gov/pubmed/7833471