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Friedrich Koch-Nolte

Name of the laboratory

Laboratory of Molecular Immunology
Institute of Immunology
University Medical Center Hamburg-Eppendorf
Martinistr. 42
20246 Hamburg, Germany

Members of the laboratory

Members: Laboratory of Molecular Immunology
Unit Leader
Friedrich Koch-Nolte
Research Fellows
Stephan Menzel
Nicole Schwarz
Thomas Eden
Anna Eichhoff
Mirjam Loew
Fabienne Seyfried
Gudrun Dubberke
Birte Albrecht
Ph.D. Students
Carolina Pinto
Thomas Eden
Anna Eichhoff
Intissar Chachbani
Tobias Schaefer
Julia Hambach

Research activities

The focus of our laboratory is on the molecular characterization of lymphocyte membrane proteins, in particular receptors and enzymes involved in signaling by extracellular nucleotides. We generate monoclonal antibodies and nanobodies - single domain antibodies derived from camelid heavy chain antibodies - as new research and therapeutic tools. We are interested in ADP-ribosylation as a pathogenic mechanism of bacterial toxins and as a reversible posttranslational modification regulating protein functions. Using genetic immunization and antibody engineering, we strive to develop new tools for combating infections and for treating diseases of the immune system. Many of our monoclonal and recombinant antibodies are commercialized via MediGate GmbH, a 100% subsidy of the University Medical Center Hamburg-Eppendorf.

Techniques available

Publications (2014-present)