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Peter Balogh

Name of the laboratory

Logo University of Pecs
Department of Immunology and Biotechnology
Clinical Center, University of Pecs
H-7634 Pecs, Szigeti ut 12

Members of the laboratory

Group leader
Dr. Peter Balogh, MD, PhD
Postdoctoral scientist/resident
Dr. Zoltan Kellermayer, MD
PhD student
Dora Vojkovics Medical Biotechnology MSc
Research associate
Diana Heidt
Research technicians
Anett Gyöngyösi

Laboratory activity

The Department of Immunology and Biotechnology (formerly "Immunological and Biotechnological Laboratory") was established in 1991 by Dr. Peter Nemeth as an independent teaching, research and diagnostic unit of the University Medical School of Pécs. This unit was dedicated to pursue its own research in basic and applied immunology, particularly to produce monoclonal antibodies for research and diagnostic purposes, now headed by Dr. Timea Berki.

The research interest of Dr Peter Balogh’s group focuses on the structure, organization and developmental features of the stromal constituents of peripheral lymphoid tissues and their role in lymphocyte homeostasis, particularly the role of Nkx2-3 transcription factor in the spleen and Peyer’s patches of mice. In this work several rat monoclonal antibodies have been generated against both hematopoietic and stromal cells (fibroblastic reticular cells, marginal zone macrophages, various endothelial subsets). Current investigations are conducted to study the impact of Nkx2-3 on the onset of inflammatory bowel diseases in various murine models and the mechanism of lymphoid tissue-specific tropism in B-cell lymphoma progression.

Research activities

Analysis of stromal constituents in either mouse of human lymphoid tissues significantly lags behind the extensive knowledge concerning the diverse spectrum of hematopoietic elements, despite recent advances using lineage tracing and fate mapping experiments. Furthermore, it remains questionable to what extent the developmental and functional characteristics in mice can be relevant to humans. Recently Nkx2-3 has emerged as an important element in organizing the stromal scaffolding in mouse spleen and Peyer’s patches, and it may also influence perturbed gut immunity in humans leading to various forms of inflammatory bowel diseases. To study the role of Nkx2-3 transcription factor, Nkx2-3-deficient mice (developed by Oliver Pabst at the Technical University of Braunschweig) have been used in various compound mutations (Ltbr-/-, Rag2-/- and now in variants allowing lymphocyte distribution analysis through Luc and photoconvertible KikGR detection) are investigated. We found that the absence of this factor essentially reprograms the spleen and Peyer’s patches vasculature towards lymph node-like pattern, including the formation of ectopic HEVs expressing PNAd and abortive LYVE-1-positive lymphatic cysts. In this work we use multiparametric flow cytometry, adoptive cell transfer and bone marrow chimeric animals as well as four-color immunofluorescent analysis of the mucosal lymphoid compartments.

Techniques available

Publications (2014-present)