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Regina Feederle

Name of the laboratory

Helmholtz Zentrum München
Core Facility Monoclonal Antibodies
Helmholtz Zentrum München
Ingolstädter Landstrasse 1
85764 Neuherberg, Germany
+49 (0)89 3187 1360

Members of the laboratory

Head of Core
Technical staff

Laboratory activity

The Core Facility Monoclonal Antibodies provides complete support for all steps of custom monoclonal antibody production, from antigen design to antibody validation and purification with more than 25 years of experience. We are open to internal and external partners from academia and industry.

Our service encompasses antigen design, immunization of rats and mice, screening and establishment of custom monoclonal antibodies and the supply of established antibodies. Furthermore, we provide purification and labelling of monoclonal antibodies, samples of commonly used control and secondary antibodies and a secured long term-storage of hybridoma clones.

We use hybridoma technology to generate thousands of clones per immunized animal which are then analyzed in an automated high-throughput flow cytometry screening platform according to the specific project requirements. We also design ELISA assays to identify high-affinity binders or neutralizing antibodies in the primary screening. A thorough antibody validation is performed in collaboration with our partners. Specific hybridoma clones are then subcloned to obtain stable monoclonal cell lines which are cryo conserved to guarantee an unlimited antibody source.

We have generated antibodies against difficult targets such as transmembrane proteins, post-translationally modified proteins, small molecules and surface proteins on cells, virus-like particles or extracellular vesicles. We frequently license antibodies with high value for the research community to industry partners. To archive the DNA sequences or for futher antibody engineering, we also provide recombinant antibody cloning.

Techniques available

  • Monoclonal antibody production from mice and rats
  • Automated high-throughput flow cytometry screening (Tecan, iQue Screener)
  • Large-scale antibody purification (Äkta systems)
  • Antibody conjugation (fluorescent labels, enzymes, biotin)
  • Endotoxin measurement and removal for in vivo applications
  • Recombinant hybridoma cloning
  • Mycoplasma testing


The Core Facility is a member of the Munich Cluster for Systems Neurology SyNergy and the German Center for Neurodegenerative Diseases DZNE.

Publications (2018-present)

  • Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity. O'Neill AC, Uzbas F, Antognolli G, Merino F, Draganova K, Jäck A, Zhang S, Pedini G, Schessner JP, Cramer K, Schepers A, Metzger F, Esgleas M, Smialowski P, Guerrini R, Falk S, Feederle R, Freytag S, Wang Z, Bahlo M, Jungmann R, Bagni C, Borner GHH, Robertson SP, Hauck SM, Götz M. Science. 2022 Jun 17;376(6599):eabf9088. doi: 10.1126/science.abf9088. Epub 2022 Jun 17. PMID: 35709258
  • Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis. Feilen LP, Chen SY, Fukumori A, Feederle R, Zacharias M, Steiner H. Elife. 2022 May 17;11:e76090. doi: 10.7554/eLife.76090. Online ahead of print. PMID: 35579427
  • PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes. Wang J, Onogi Y, Krueger M, Oeckl J, Karlina R, Singh I, Hauck SM, Feederle R, Li Y, Ussar S. Mol Metab. 2022 Jul;61:101508. doi: 10.1016/j.molmet.2022.101508. Epub 2022 May 2. PMID: 35513259 Free PMC article.
  • FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Preisendörfer S, Ishikawa Y, Hennen E, Winklmeier S, Schupp JC, Knüppel L, Fernandez IE, Binzenhöfer L, Flatley A, Juan-Guardela BM, Ruppert C, Guenther A, Frankenberger M, Hatz RA, Kneidinger N, Behr J, Feederle R, Schepers A, Hilgendorff A, Kaminski N, Meinl E, Bächinger HP, Eickelberg O, Staab-Weijnitz CA. Cells. 2022 Apr 14;11(8):1341. doi: 10.3390/cells11081341. PMID: 35456020 Free PMC article.
  • A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape. Kellner M, von Neubeck B, Czogalla B, Feederle R, Vick B, Jeremias I, Zeidler R. Biomedicines. 2022 Mar 31;10(4):825. doi: 10.3390/biomedicines10040825. PMID: 35453575 Free PMC article.
  • Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study. Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C; Dominantly Inherited Alzheimer Network. Lancet Neurol. 2022 Apr;21(4):329-341. doi: 10.1016/S1474-4422(22)00027-8. PMID: 35305339 Free PMC article.
  • Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43. Garcia Morato J, Hans F, von Zweydorf F, Feederle R, Elsässer SJ, Skodras AA, Gloeckner CJ, Buratti E, Neumann M, Kahle PJ. Nat Commun. 2022 Mar 9;13(1):1223. doi: 10.1038/s41467-022-28822-7. PMID: 35264561 Free PMC article.
  • Phosphorylation of serine-893 in CARD11 suppresses the formation and activity of the CARD11-BCL10-MALT1 complex in T and B cells. Kutzner K, Woods S, Karayel O, Gehring T, Yin H, Flatley A, Graß C, Wimberger N, Tofaute MJ, Seeholzer T, Feederle R, Mann M, Krappmann D. Sci Signal. 2022 Mar;15(723):eabk3083. doi: 10.1126/scisignal.abk3083. Epub 2022 Mar 1. PMID: 35230873
  • An Antibody-Aptamer-Hybrid Lateral Flow Assay for Detection of CXCL9 in Antibody-Mediated Rejection after Kidney Transplantation. Seiler LK, Phung NL, Nikolin C, Immenschuh S, Erck C, Kaufeld J, Haller H, Falk CS, Jonczyk R, Lindner P, Thoms S, Siegl J, Mayer G, Feederle R, Blume CA. Diagnostics (Basel). 2022 Jan 25;12(2):308. doi: 10.3390/diagnostics12020308. PMID: 35204399 Free PMC article.
  • Normality sensing licenses local T cells for innate-like tissue surveillance. McKenzie DR, Hart R, Bah N, Ushakov DS, Muñoz-Ruiz M, Feederle R, Hayday AC. Nat Immunol. 2022 Mar;23(3):411-422. doi: 10.1038/s41590-021-01124-8. Epub 2022 Feb 14. PMID: 35165446 Free PMC article.
  • Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs. Schöller E, Marks J, Marchand V, Bruckmann A, Powell CA, Reichold M, Mutti CD, Dettmer K, Feederle R, Hüttelmaier S, Helm M, Oefner P, Minczuk M, Motorin Y, Hafner M, Meister G. Mol Cell. 2021 Dec 2;81(23):4810-4825.e12. doi: 10.1016/j.molcel.2021.10.018. Epub 2021 Nov 12. PMID: 34774131
  • Localisation of cryptochrome 2 in the avian retina. Einwich A, Seth PK, Bartölke R, Bolte P, Feederle R, Dedek K, Mouritsen H. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2022 Jan;208(1):69-81. doi: 10.1007/s00359-021-01506-1. Epub 2021 Oct 22. PMID: 34677638 Free PMC article.
  • MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling. Xin S, Mueller C, Pfeiffer S, Kraft VAN, Merl-Pham J, Bao X, Feederle R, Jin X, Hauck SM, Schmitt-Kopplin P, Schick JA. Cell Death Differ. 2022 Mar;29(3):670-686. doi: 10.1038/s41418-021-00883-z. Epub 2021 Oct 18. PMID: 34663908 Free PMC article.
  • Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation. Hoefig KP, Reim A, Gallus C, Wong EH, Behrens G, Conrad C, Xu M, Kifinger L, Ito-Kureha T, Defourny KAY, Geerlof A, Mautner J, Hauck SM, Baumjohann D, Feederle R, Mann M, Wierer M, Glasmacher E, Heissmeyer V. Nat Commun. 2021 Sep 1;12(1):5208. doi: 10.1038/s41467-021-25345-5. PMID: 34471108 Free PMC article.
  • PRMT1 promotes the tumor suppressor function of p14ARF and is indicative for pancreatic cancer prognosis. Repenning A, Happel D, Bouchard C, Meixner M, Verel-Yilmaz Y, Raifer H, Holembowski L, Krause E, Kremmer E, Feederle R, Keber CU, Lohoff M, Slater EP, Bartsch DK, Bauer UM. EMBO J. 2021 Jul 1;40(13):e106777. doi: 10.15252/embj.2020106777. Epub 2021 May 17. PMID: 33999432 Free PMC article.
  • Chemokine-like MDL proteins modulate flowering time and innate immunity in plants. Gruner K, Leissing F, Sinitski D, Thieron H, Axstmann C, Baumgarten K, Reinstädler A, Winkler P, Altmann M, Flatley A, Jaouannet M, Zienkiewicz K, Feussner I, Keller H, Coustau C, Falter-Braun P, Feederle R, Bernhagen J, Panstruga R. J Biol Chem. 2021 Jan-Jun;296:100611. doi: 10.1016/j.jbc.2021.100611. Epub 2021 Mar 30. PMID: 33798552 Free PMC article.
  • Author Correction: Inceptor counteracts insulin signalling in β-cells to control glycaemia. Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Nature. 2021 Apr;592(7852):E1. doi: 10.1038/s41586-021-03347-z. PMID: 33712809 No abstract available.
  • Inceptor counteracts insulin signalling in β-cells to control glycaemia. Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Nature. 2021 Feb;590(7845):326-331. doi: 10.1038/s41586-021-03225-8. Epub 2021 Jan 27. PMID: 33505018
  • A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN. Zhao S, Kieser A, Li HY, Reinking HK, Weickert P, Euteneuer S, Yaneva D, Acampora AC, Götz MJ, Feederle R, Stingele J. Nucleic Acids Res. 2021 Jan 25;49(2):902-915. doi: 10.1093/nar/gkaa1224. PMID: 33348378 Free PMC article.
  • A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region. Ibach M, Mathews M, Linnartz-Gerlach B, Theil S, Kumar S, Feederle R, Brüstle O, Neumann H, Walter J. Glia. 2021 May;69(5):1126-1139. doi: 10.1002/glia.23953. Epub 2020 Dec 14. PMID: 33314333
  • Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS. Gerhards R, Pfeffer LK, Lorenz J, Starost L, Nowack L, Thaler FS, Schlüter M, Rübsamen H, Macrini C, Winklmeier S, Mader S, Bronge M, Grönlund H, Feederle R, Hsia HE, Lichtenthaler SF, Merl-Pham J, Hauck SM, Kuhlmann T, Bauer IJ, Beltran E, Gerdes LA, Mezydlo A, Bar-Or A, Banwell B, Khademi M, Olsson T, Hohlfeld R, Lassmann H, Kümpfel T, Kawakami N, Meinl E. Acta Neuropathol Commun. 2020 Nov 30;8(1):207. doi: 10.1186/s40478-020-01086-2. PMID: 33256847 Free PMC article.
  • Novel antibody against low-n oligomers of tau protein promotes clearance of tau in cells via lysosomes. Chandupatla RR, Flatley A, Feederle R, Mandelkow EM, Kaniyappan S. Alzheimers Dement (N Y). 2020 Oct 28;6(1):e12097. doi: 10.1002/trc2.12097. eCollection 2020. PMID: 33145390 Free PMC article.
  • Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice. Degenhardt K, Wagner J, Skodras A, Candlish M, Koppelmann AJ, Wild K, Maxwell R, Rotermund C, von Zweydorf F, Gloeckner CJ, Davies HA, Madine J, Del Turco D, Feederle R, Lashley T, Deller T, Kahle P, Hefendehl JK, Jucker M, Neher JJ. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23925-23931. doi: 10.1073/pnas.2011133117. Epub 2020 Sep 8. PMID: 32900929 Free PMC article.
  • Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice. Sato M, Onuma K, Domon M, Hasegawa S, Suzuki A, Kusumi R, Hino R, Kakihara N, Kanda Y, Osaki M, Hamada J, Bannai S, Feederle R, Buday K, Angeli JPF, Proneth B, Conrad M, Okada F, Sato H. Int J Cancer. 2020 Dec 1;147(11):3224-3235. doi: 10.1002/ijc.33262. Epub 2020 Aug 26. PMID: 32818320
  • Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments. Jandke A, Melandri D, Monin L, Ushakov DS, Laing AG, Vantourout P, East P, Nitta T, Narita T, Takayanagi H, Feederle R, Hayday A. Nat Commun. 2020 Jul 28;11(1):3769. doi: 10.1038/s41467-020-17557-y. PMID: 32724083 Free PMC article.
  • Validation strategies for antibodies targeting modified ribonucleotides. Weichmann F, Hett R, Schepers A, Ito-Kureha T, Flatley A, Slama K, Hastert FD, Angstman NB, Cardoso MC, König J, Hüttelmaier S, Dieterich C, Canzar S, Helm M, Heissmeyer V, Feederle R, Meister G. RNA. 2020 Oct;26(10):1489-1506. doi: 10.1261/rna.076026.120. Epub 2020 Jul 7. PMID: 32636310 Free PMC article.
  • Spt6 is a maintenance factor for centromeric CENP-A. Bobkov GOM, Huang A, van den Berg SJW, Mitra S, Anselm E, Lazou V, Schunter S, Feederle R, Imhof A, Lusser A, Jansen LET, Heun P. Nat Commun. 2020 Jun 10;11(1):2919. doi: 10.1038/s41467-020-16695-7. PMID: 32522980 Free PMC article.
  • A family of hyperpolarization-activated channels selective for protons. Wobig L, Wolfenstetter T, Fechner S, Bönigk W, Körschen HG, Jikeli JF, Trötschel C, Feederle R, Kaupp UB, Seifert R, Berger TK. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13783-13791. doi: 10.1073/pnas.2001214117. Epub 2020 May 28. PMID: 32467169 Free PMC article.
  • Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome. Žaja R, Aydin G, Lippok BE, Feederle R, Lüscher B, Feijs KLH. Sci Rep. 2020 May 19;10(1):8286. doi: 10.1038/s41598-020-64623-y. PMID: 32427867 Free PMC article.
  • Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, Sülzen A, Nuscher B, Hampel H, Xiang X, Feederle R, Tahirovic S, Park JI, Prorok R, Mahon C, Liang CC, Shi J, Kim DJ, Sabelström H, Huang F, Di Paolo G, Simons M, Lewcock JW, Haass C. EMBO Mol Med. 2020 Apr 7;12(4):e11227. doi: 10.15252/emmm.201911227. Epub 2020 Mar 10. PMID: 32154671 Free PMC article.
  • ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1). Weskamp G, Tüshaus J, Li D, Feederle R, Maretzky T, Swendemann S, Falck-Pedersen E, McIlwain DR, Mak TW, Salmon JE, Lichtenthaler SF, Blobel CP. J Biol Chem. 2020 Mar 27;295(13):4350-4358. doi: 10.1074/jbc.RA119.011136. Epub 2020 Feb 14. PMID: 32060096 Free PMC article.
  • Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins. Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R. EMBO Rep. 2019 Mar;20(3):e46451. doi: 10.15252/embr.201846451. Epub 2019 Feb 7. PMID: 32048434
  • Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1. Rudan Njavro J, Klotz J, Dislich B, Wanngren J, Shmueli MD, Herber J, Kuhn PH, Kumar R, Koeglsperger T, Conrad M, Wurst W, Feederle R, Vlachos A, Michalakis S, Jedlicka P, Müller SA, Lichtenthaler SF. FASEB J. 2020 Feb;34(2):2465-2482. doi: 10.1096/fj.201902347R. Epub 2019 Dec 27. PMID: 31908000
  • Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model. Zhou Q, Mareljic N, Michaelsen M, Parhizkar S, Heindl S, Nuscher B, Farny D, Czuppa M, Schludi C, Graf A, Krebs S, Blum H, Feederle R, Roth S, Haass C, Arzberger T, Liesz A, Edbauer D. EMBO Mol Med. 2020 Feb 7;12(2):e10919. doi: 10.15252/emmm.201910919. Epub 2019 Dec 20. PMID: 31858749 Free PMC article.
  • Author Correction: The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels. Simons IM, Mohrlüder J, Feederle R, Kremmer E, Zobel T, Dobner J, Bleffert N, Hoffmann S, Willbold D. Sci Rep. 2019 Dec 11;9(1):19221. doi: 10.1038/s41598-019-55814-3. PMID: 31822784 Free PMC article.
  • Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation. Trambauer J, Rodríguez Sarmiento RM, Fukumori A, Feederle R, Baumann K, Steiner H. EMBO Rep. 2020 Jan 7;21(1):e47996. doi: 10.15252/embr.201947996. Epub 2019 Nov 25. PMID: 31762188 Free PMC article.
  • MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells. Gehring T, Erdmann T, Rahm M, Graß C, Flatley A, O'Neill TJ, Woods S, Meininger I, Karayel O, Kutzner K, Grau M, Shinohara H, Lammens K, Feederle R, Hauck SM, Lenz G, Krappmann D. Cell Rep. 2019 Oct 22;29(4):873-888.e10. doi: 10.1016/j.celrep.2019.09.040. PMID: 31644910
  • Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein. Gomes LA, Hipp SA, Rijal Upadhaya A, Balakrishnan K, Ospitalieri S, Koper MJ, Largo-Barrientos P, Uytterhoeven V, Reichwald J, Rabe S, Vandenberghe R, von Arnim CAF, Tousseyn T, Feederle R, Giudici C, Willem M, Staufenbiel M, Thal DR. Acta Neuropathol. 2019 Dec;138(6):913-941. doi: 10.1007/s00401-019-02053-5. Epub 2019 Aug 14. PMID: 31414210
  • Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3. von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E. J Exp Med. 2019 Jul 1;216(7):1700-1723. doi: 10.1084/jem.20181762. Epub 2019 May 24. PMID: 31126966 Free PMC article.
  • Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins. Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R. EMBO Rep. 2019 May;20(5):e48133. doi: 10.15252/embr.201948133. PMID: 31061204 Free PMC article.
  • Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development. Matheus F, Rusha E, Rehimi R, Molitor L, Pertek A, Modic M, Feederle R, Flatley A, Kremmer E, Geerlof A, Rishko V, Rada-Iglesias A, Drukker M. Stem Cell Reports. 2019 May 14;12(5):861-868. doi: 10.1016/j.stemcr.2019.03.006. Epub 2019 Apr 18. PMID: 31006630 Free PMC article.
  • The centrosome protein AKNA regulates neurogenesis via microtubule organization. Camargo Ortega G, Falk S, Johansson PA, Peyre E, Broix L, Sahu SK, Hirst W, Schlichthaerle T, De Juan Romero C, Draganova K, Vinopal S, Chinnappa K, Gavranovic A, Karakaya T, Steininger T, Merl-Pham J, Feederle R, Shao W, Shi SH, Hauck SM, Jungmann R, Bradke F, Borrell V, Geerlof A, Reber S, Tiwari VK, Huttner WB, Wilsch-Bräuninger M, Nguyen L, Götz M. Nature. 2019 Mar;567(7746):113-117. doi: 10.1038/s41586-019-0962-4. Epub 2019 Feb 20. PMID: 30787442
  • Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R. EMBO Rep. 2019 Mar;20(3):e46451. doi: 10.15252/embr.201846451. Epub 2019 Feb 7. PMID: 30733281 Free PMC article.
  • The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7. Köhler K, Sanchez-Pulido L, Höfer V, Marko A, Ponting CP, Snijders AP, Feederle R, Schepers A, Boos D. PLoS Biol. 2019 Jan 29;17(1):e2006767. doi: 10.1371/journal.pbio.2006767. eCollection 2019 Jan. PMID: 30695077 Free PMC article.
  • The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels. Simons IM, Mohrlüder J, Feederle R, Kremmer E, Zobel T, Dobner J, Bleffert N, Hoffmann S, Willbold D. Sci Rep. 2019 Jan 24;9(1):526. doi: 10.1038/s41598-018-36717-1. PMID: 30679523 Free PMC article.
  • Plk1/Polo Phosphorylates Sas-4 at the Onset of Mitosis for an Efficient Recruitment of Pericentriolar Material to Centrosomes. Ramani A, Mariappan A, Gottardo M, Mandad S, Urlaub H, Avidor-Reiss T, Riparbelli M, Callaini G, Debec A, Feederle R, Gopalakrishnan J. Cell Rep. 2018 Dec 26;25(13):3618-3630.e6. doi: 10.1016/j.celrep.2018.11.102. PMID: 30590037
  • Determination of enrichment factors for modified RNA in MeRIP experiments. Slama K, Galliot A, Weichmann F, Hertler J, Feederle R, Meister G, Helm M. Methods. 2019 Mar 1;156:102-109. doi: 10.1016/j.ymeth.2018.10.020. Epub 2018 Oct 28. PMID: 30394295
  • Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes. Bouchard C, Sahu P, Meixner M, Nötzold RR, Rust MB, Kremmer E, Feederle R, Hart-Smith G, Finkernagel F, Bartkuhn M, Savai Pullamsetti S, Nist A, Stiewe T, Philipsen S, Bauer UM. Cell Rep. 2018 Sep 18;24(12):3339-3352. doi: 10.1016/j.celrep.2018.08.052. PMID: 30232013
  • Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers. Frick P, Sellier C, Mackenzie IRA, Cheng CY, Tahraoui-Bories J, Martinat C, Pasterkamp RJ, Prudlo J, Edbauer D, Oulad-Abdelghani M, Feederle R, Charlet-Berguerand N, Neumann M. Acta Neuropathol Commun. 2018 Aug 3;6(1):72. doi: 10.1186/s40478-018-0579-0. PMID: 30075745 Free PMC article.
  • Click Chemistry-mediated Biotinylation Reveals a Function for the Protease BACE1 in Modulating the Neuronal Surface Glycoproteome. Herber J, Njavro J, Feederle R, Schepers U, Müller UC, Bräse S, Müller SA, Lichtenthaler SF. Mol Cell Proteomics. 2018 Aug;17(8):1487-1501. doi: 10.1074/mcp.RA118.000608. Epub 2018 May 1. PMID: 29716987 Free PMC article.
  • Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription. Bütepage M, Preisinger C, von Kriegsheim A, Scheufen A, Lausberg E, Li J, Kappes F, Feederle R, Ernst S, Eckei L, Krieg S, Müller-Newen G, Rossetti G, Feijs KLH, Verheugd P, Lüscher B. Sci Rep. 2018 Apr 30;8(1):6748. doi: 10.1038/s41598-018-25137-w. PMID: 29712969 Free PMC article.
  • Non-cell-autonomous function of DR6 in Schwann cell proliferation. Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld T, Lichtenthaler SF. EMBO J. 2018 Apr 3;37(7):e97390. doi: 10.15252/embj.201797390. Epub 2018 Feb 19. PMID: 29459438 Free PMC article.
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